Scientific Publications

The following papers by Dr. Lechner/ coauthors have been accepted for publication in international journals and in PubMed because of their academic excellence. All papers are peer-reviewed and thus scientifically acknowledged and part of discussion in the scientific community. These studies provide new evidence supporting a significant relationship between fatty-degenerative jawbone (FDOJ), jawbone osteonecrosis (JON/“NICO”) and the subsequent risk of immunological and systemic/neurodegenerative diseases like cancer, neurodegenerative and autoimmune diseases, inflammation, arthritis and CNS disorders. Hopefully this is another step to getting acknowledged fatty-degenerative osteopathias and silent inflammation in jawbone (FDOJ/JON/“NICO”) in mainstream medicine and dentistry.

 

1. In June 2010 the European Journal of Integrative Medicine published my paper:  “Immune messengers in Neuralgia Inducing Cavitational Osteonecrosis (NICO) in jaw bone and systemic interference”.
Download under: http://dx.doi.org/10.1016/j.eujim.2010.03.004
Link in ScienceDirect (Elsevier): http://www.sciencedirect.com/science/article/pii/S1876382010000260

Conclusion: This pilot study with only 6 samples was the first to show high concentration on RANTES in silent inflammation in jawbone despite the high number of 27 tested mediators.

 

2. In April 2013 the International Journal of General Medicine accepted my paper::  "RANTES and fibroblast growth factor 2 in jawbone cavitations triggers for systemic disease":
Free download: http://www.dovepress.com/articles.php?article_id=12842&l=bBexMykzNGYEHIPfWZ1MT6xu198194
On the journal`s website you find a button “Metrics”: Since the paper went online in April 2013 we have more than 30.000 total views.
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23637551

Conclusion: This study suggests that FDOJ/JON/”NICO” might serve as a fundamental cause of immune diseases, through overexpressed RANTES andFGF-2 production. Thus, FDOJ/JON/”NICO” and implicated immune messengers serve as a possible cause. Removing FDOJ/JON/”NICO” may be a key to reversing systemic diseases.

 

3. In Mai 2014 the Journal of Breast Cancer: Basic and Clinical Research accepted my paper: „Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients—Case Report and Research”.
Free download: http://la-press.com/article.php?article_id=4214
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24899812

Conclusion: Data confirm that FDOJ/JON/”NICO” produces high levels of RANTES, a cytokine implicated in breast cancer and metastasis. Levels detected in FDOJ/JON/”NICO”  are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa. We thus hypothesize that FDOJ/JON/”NICO” may serve as an expeditor of MaCa progression, through RANTES production.

 

4. In August 2014 the Journal Clinical, Cosmetic and Investigational Dentistry published my paper: “Validation of dental X-ray by cytokine RANTES – comparison of X-ray findings with cytokine overexpression in jawbone”.
Free download under: http://www.dovepress.com/articles.php?article_id=18049.
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25170282

Conclusion: Comparisons of the data revealed a discrepancy between the X-ray density of dental 2D-OPGs and osteopathies in the jawbone like FDOJ/JON/”NICO”.. The data suggest a critical attitude toward the use of 2D-OPG as a sole imaging diagnostic tool for assessing chronic inflammatory processes in the jawbone. Specifically, 2D-OPG is objectively not suitable for depicting FDOJ.



5. In March 2015: International Journal of General Medicine: “Stimulation of proinflammatory cytokines by volatile sulfur compounds in endodontically-treated teeth”.
Free download under: http://dx.doi.org/10.2147/IJGM.S77693
Link in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/25792853

Conclusion: Persistent microorganisms in endodontically-treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide and thioether. The association between ex vivo-stimulated cytokines and endodontically-derived sulfur components is supported by the fact that the number of interferon gamma and/or interleukin-10-positive sensitized patients declined significantly 3–8 months after extraction of the corresponding teeth. A semi-quantitative chair side test for VSC on teeth with root fillings is in correlation to IFNg and Il-10 sensitization in blood cells.

 

6. In May 2015:. EPMA Journal (European Association for Predictive, Preventive and Personalized Medicine): “Chemokine RANTES/CCL5 as an unknown link between wound healing in the jawbone and systemic disease: is prediction and tailored treatments in the horizon?”.2015, 6:10. doi:10.1186/s13167-015-0032-4
Free download under: http://www.epmajournal.com/content/6/1/10
Link in PubMed: (in progress)

Conclusion: Dentists set off defective wound healing in the jawbone in ignorance of its connection to inflammatory mediators and the possibility of it being a hidden cause of chronic systemic diseases. 16 samples of jawbone were examined for seven cytokines by multiplex analysis All fatty necrotic and osteolytic jawbone (FDOJ) samples showed RANTES and fibroblast growth factor (FGF)-2 as the only extremely overexpressed cytokines. Areas of improper and incomplete wound healing (FDOJ) might act as hyperactivated signaling pathways, while serving as an unknown source of “silent inflammation”.

 

7.    In June 2015: Evidence-Based Complementary and Alternative Medicine “Peripheral Neuropathic Facial/Trigeminal Pain and RANTES/CCL5 in Jawbone Cavitation”, Vol. 2015, Article ID 582520, 9 pages, 2015. doi:10.1155/2015/582520
Free download under: http://www.hindawi.com/journals/ecam/2015/582520/
Table of Contents of Volume 2015: http://www.hindawi.com/journals/ecam/contents/
Link in PubMed: (in progress)


Conclusion: Hollow dead spaces in the jawbone known popularly as “cavitations,” and as “NICO,” might serve as a fundamental cause of neuropathic pain, through the inflammatory cytokines that they produce. Opioid receptors mediate anti-pain responses in both the peripheral and central nervous systems, and RANTES is able to enhance the pain response. Data demonstrate the local overexpression of RANTES/CCL5 in fatty degenerated jawbones (FDOJ) as a possible cause of atypical facial pain and Trigeminal Neuralgia (AFP/TRN. Treatment for FDOJ requires surgical debridement what can diminish RANTES overexpression and thus reduce chronic facial pain. Many case histories in the author`s clinic show in removing the diseased FDOJ from the jawbone may be the key to reversing AFP/TRN.